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KMID : 0350519940470010483
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Journal of Catholic Medical College
1994 Volume.47 No. 1 p.483 ~ p.494
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Tissue Damage following Subcutaneous Injection of Gd-DTPA in Rats
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Abstract
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Gadolinium-diethylenetriaminepentaacetic acid/dimeglumine(Gd-DTPA) approved by the FDA(Food and Drug Administration) for clinical use has been known to be extremely safe in comparison with iodinated contrast media used in computed tomography(CT).
The purpose of this study was to evaluate the tissue damage following subcutaneous injection of various osmolalities of Gd-DTPA with or without vascular impairment.
Total 242 feet from 121 rats were divided into 7 groups according to injected agents and injection time. All groups were also divided into 3 subgroups(subgroup 1, no ligation of femoral vessel ; subgroup 2, ligation of femoral artery ; subgroup
3,
ligation of femoral vein). The solution of 0.4 ml of various osmolalities of Gd-DTPA and sodium chloride solution(NaC1) were injected subcutaneously into the dorsum of hind feet. All rats were grossly examined to evaluate the tissue damage for
two
weeks
after the injection. Histopathological examinations were performed in order to evaluate the correlation with the representative gross changes.
@ES The results were as follows:
@EN 1. The lower osmolality of Gd-DTPA, the milder tissue damage was shown.
2. At the same osmolality, Gd-DTPA occurred more severe damage as compared with that in the injection of NaCl solution.
3. The tissue damage due to the Gd-DTPA injection was more severe in the vascular impairment.
4. The tissue damage due to the Gd-DTPA injection was severe when ligated the artery as compared with that the group of venous ligation.
5. No significant difference of tissue damage was shown between the Gd-DTPA injection group immediately after the ligation of the vessel and the group 3 days after the ligation.
These results indicate that the extravasated Gd-DTPA is one of the risk factors in case of the patients having vascular impairment, since Gd-DTPA injection induces more severe inflammatory reaction when blood vessles are impaired.
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